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CME on Spasticity is dedicated to online CME conferences, courses and presentations (slides with voice over) on spasticity, given by local and international experts. Its mission is to keep you up-to-date with the most recent developments on spasticity.
 Presentation
"Management of Spasticity Associated with Multiple Sclerosis"
Dr. Mark Freedman (biography)
English - 2004-04-02 - 32 minutes
(46 slides)

Summary :
Dr.Freedman’s talk covers the etiology, symptoms, and complications of spasticity in MS patients and a review of pharmacologic and non-pharmacologic symptom management.

The MS patient with spasticity suffers from limitations on his activities of daily living. The goal of treatment is therefore to improve the patient’s functionality and quality of life while decreasing concomitant pain and discomfort. The pendulum test can be used to obtain an objective rating of spasticity and is a useful tool to assess progress over time. Dr. Freedman discusses the evidence supporting various therapeutic options, ranging from combination pharmacotherapy to acupuncture, that can be applied alone or in combination to treat spasticity in MS patients.

Copyright © 2004 E-MedHosting.com Inc.

Learning objectives :
To review non-pharmacologic interventions and medications currently available for management of spasticity in MS patients.

To discuss evidence-based and expert opinion-based approaches to palliative care of spasticity.

Bibliographic references :
Groves L, Shellenberger MK, Davis CS. Tizanidine treatment of spasticity: a meta-analysis of controlled, double-blind, comparative studies with baclofen and diazepam. Adv Ther. 1998 Jul-Aug;15(4):241-51.

Hennies OL. A new skeletal muscle relaxant (DS 103-282) compared to diazepam in the treatment of muscle spasm of local origin. J Int Med Res. 1981;9(1):62-8.

Hoogstraten MC, van der Ploeg RJ, vd Burg W, Vreeling A, van Marle S, Minderhoud JM. Tizanidine versus baclofen in the treatment of spasticity in multiple sclerosis patients. Acta Neurol Scand. 1988 Mar;77(3):224-30.

Lepisto F. A Comparative Trial of Tizanidine and Placebo in Patients with Skeletal Muscle Spasms After Operation for Herniated Disk. Current Therapeutic Research. 1981; 30(2):141-146.

Nance PW, Sheremata WA, Lynch SG, Vollmer T, Hudson S, Francis GS, O'Connor P, Cohen JA, Schapiro RT, Whitham R, Mass MK, Lindsey JW, Shellenberger K. Relationship of the antispasticity effect of tizanidine to plasma concentration in patients with multiple sclerosis. Arch Neurol. 1997 Jun;54(6):731-6.

Nance PW, Bugaresti J, Shellenberger K, Sheremata W, Martinez-Arizala A. Efficacy and safety of tizanidine in the treatment of spasticity in patients with spinal cord injury. North American Tizanidine Study Group. Neurology. 1994 Nov;44(11 Suppl 9):S44-51; discussion S51-2.

Paisley S, Beard S, Hunn A, Wight J. Clinical effectiveness of oral treatments for spasticity in multiple sclerosis: a systematic review. Mult Scler. 2002 Aug;8(4):319-29.

Smolenski C, Muff S, Smolenski-Kautz S. A double-blind comparative trial of new muscle relaxant, tizanidine (DS 103-282), and baclofen in the treatment of chronic spasticity in multiple sclerosis. PMID: 7016449 [PubMed - indexed for MEDLINE]

United Kingdom Tizanidine Trial Group. A double-blind comparative trial of new muscle relaxant, tizanidine (DS 103-282), and baclofen in the treatment of chronic spasticity in multiple sclerosis. Neurology, 1994 Nov; 44: 70S - 78.

   


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